Ku70 + Ku80 Antibody | V7202SAF-100UG

Ku70 + Ku80 Antibody | V7202SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: LKAP1-1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: FACS, IF

Buffer: N/A

Limitation: This Ku70 + Ku80 antibody is available for research use only.

Purity: Protein G purified

Description: Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. It is also required for V(D)J recombination, which utilizes the NHEJ pathway to promote antigen diversity in the mammalian immune system. In addition to its role in NHEJ, Ku is also required for telomere length maintenance and subtelomeric gene silencing. Ku was originally identified when patients with systemic lupus erythematosus were found to have high levels of autoantibodies to the protein. [Wiki]

Immunogen: A human cell nuclear fraction was used as the immunogen for this Ku70 + Ku80 antibody.

Storage: Store the Ku70 + Ku80 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).