KRT15 Antibody / Cytokeratin 15 | V3455SAF-100UG

KRT15 Antibody / Cytokeratin 15 | V3455SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: SPM190

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC

Buffer: N/A

Limitation: This Cytokeratin 15 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

Immunogen: An amino acid sequence from the C-terminal portion of the human protein was used as the immunogen for the Cytokeratin 15 antibody.

Storage: Store the Cytokeratin 15 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).