KRT10 Antibody / Cytokeratin 10 | V9057IHC-7ML

KRT10 Antibody / Cytokeratin 10 | V9057IHC-7ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

Format: Purified

Clone: SPM261

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This Cytokeratin 10 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Immunogen: Skin extract of a human Psoriasis patient were used as the immunogen for this Cytokeratin 10 antibody.

Storage: Store the Cytokeratin 10 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).