KRT10 Antibody / Cytokeratin 10 | V2174SAF-100UG

KRT10 Antibody / Cytokeratin 10 | V2174SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: LH2

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse

Application: WB, IHC-P

Buffer: N/A

Limitation: This Cytokeratin 10 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: This antibody recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). cytokeratin 10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of cytokeratin 10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, cytokeratin 10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), cytokeratin 10 is detected very frequently. Expression of cytokeratin 10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

Immunogen: Skin extract from a human psoriasis patient was used as the immunogen for this Cytokeratin 10 antibody.

Storage: Store the Cytokeratin 10 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).