Description
KIR3DL3/IL-2 Luciferase Reporter Jurkat Cell Line | 78322 | Gentaur US, UK & Europe Disrtribition
Category: NK Cells/Cell Line
Application: • Characterize the biological activity of KIR3DL3 interaction with B7-H7
• Screen for anti-B7-H7 antibodies in co-culture with B7-H7-expressing cells
Background: N/A
Description: Recombinant Jurkat cell line expressing firefly luciferase under the control of an IL-2-responsive promoter, and with constitutive expression of human KIR3DL3 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains and Long Cytoplasmic Tail 3; GenBank accession #BC143802.1 corresponding to KIR3DL3*00402 allele). HHLA2 (B7-H7) mediates an immune-stimulatory signal via TMIGD2 (Transmembrane and immunoglobulin domain containing 2; CD28H) in naïve T cells while it delivers an immune-inhibitory signal through KIR3DL3 in activated T cells and Natural Killer (NK) cells.
Product Type: Cell Line
Shippement Condition: -80°C
