Keratin 6 Antibody / Cytokeratin 6 | V3301-20UG

Keratin 6 Antibody / Cytokeratin 6 | V3301-20UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: KRT6/1702

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse

Application: IHC-P

Buffer: N/A

Limitation: This Cytokeratin 6 antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: This mAb recognizes a protein of 56kDa, identified as Cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Immunogen: Recombinant human CK6 protein was used as the immunogen for the Cytokeratin 6 antibody.

Storage: Store the Cytokeratin 6 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).