KEAP1 Antibody | F40464-0.08ML

KEAP1 Antibody | F40464-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IHC, ELISA

Buffer: N/A

Limitation: This KEAP1 antibody is available for research use only.

Purity: Antigen affinity

Description: KEAP1 acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome [UniProt]

Immunogen: A portion of amino acids 422-449 from the human protein was used as the immunogen for this KEAP1 antibody.

Storage: Store at 4oC for up to one month. For long term, aliquot the KEAP1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.