JW 55 | 27633-1

JW 55 | 27633-1 | Gentaur US, UK & Europe Disrtribition

Category: PARP/Inhibitors / Activators

Application: N/A

Background: Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin; inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; reduces cell cycle progression and proliferation in SW480 cells in vitro.

Description: Cell-permeable, reversible tankyrase 1 (PARP5a) and tankyrase 2 (PARP5b) inhibitor. Also inhibits the β-catenin mediated canonical Wnt pathway

Product Type: Inhibitor

Shippement Condition: Room temp. (continental US) or gel packs