Description
(-)-JQ1 | 27335 | Gentaur US, UK & Europe Disrtribition
Category: Bromodomain/Inhibitors / Activators
Application: N/A
Background: (-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1 competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin, which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and IC50 of 10,000 nM.
Description: N/A
Product Type: Inhibitor
Shippement Condition: room temp (domestic), gel packs international
