JNK Antibody (MAPK8) | F50464-0.08ML

JNK Antibody (MAPK8) | F50464-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: IF, IHC, WB, ELISA

Buffer: N/A

Limitation: This JNK antibody is available for research use only.

Purity: Purified

Description: JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.

Immunogen: A portion of amino acids 358-389 from the human protein was used as the immunogen for this JNK antibody.

Storage: Aliquot the JNK antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.