JARID1B (KDM5B, PLU-1), His-FLAG-tags | 50121

JARID1B (KDM5B, PLU-1), His-FLAG-tags | 50121 | Gentaur US, UK & Europe Disrtribition

Category: Demethylase/Enzymes

Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

Background: Histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-9 or H3 Lys-27. Demethylates trimethylated, dimethylated and monomethylated H3 Lys-4. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.

Description: Human JARID1B, also known as PLU-1 and KDM5B (GenBank Accession No. NM_006618), a.a. 2-751 with N-terminal His-FLAG-tag, MW=88 kDa, expressed in Sf9 cells via a baculovirus expression system.

Product Type: Protein

Shippement Condition: -80°C