IRF9 Polyclonal Antibody | E-AB-14166

IRF9 Polyclonal Antibody | E-AB-14166 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Application: WB, IHC, ELISA

Research Area: Epigenetics and Nuclear Signaling, Immunology

Background: Interferon regulatory factor 9is aproteinthat in humans is encoded by theIRF9gene, previously known as ISGF3G. Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Lead Time: 7~10 days

Concentration: 0.6 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein of human IRF9

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification: Affinity purification

Dilution: WB 1:200-1:1000, IHC 1:50-1:200

Conjugation: Unconjugated

Calculated Molecular Weight: 44 kDa

Observed Molecular Weight: N/A

Clonality: Polyclonal