IRF3 Antibody | V9201-100UG

IRF3 Antibody | V9201-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: PCRP-IRF3-6C8

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: FACS, IF, WB

Buffer: N/A

Limitation: This IRF3 antibody is available for research use only.

Purity: Protein A/G affinity

Description: In the absence of viral infection, IRF3 is maintained as a monomer in an autoinhibited state. Phosphorylation by TBK1 and IKBKE disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes. [UniProt]

Immunogen: Recombinant full-length human IRF3 protein was used as the immunogen for the IRF3 antibody.

Storage: Aliquot the IRF3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.