Description
IRF3 Antibody | V9201-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: PCRP-IRF3-6C8
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: FACS, IF, WB
Buffer: N/A
Limitation: This IRF3 antibody is available for research use only.
Purity: Protein A/G affinity
Description: In the absence of viral infection, IRF3 is maintained as a monomer in an autoinhibited state. Phosphorylation by TBK1 and IKBKE disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes. [UniProt]
Immunogen: Recombinant full-length human IRF3 protein was used as the immunogen for the IRF3 antibody.
Storage: Aliquot the IRF3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
