Description
IRF3 Antibody | F54481-0.05ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: 1522CT766.58.24
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Monkey
Application: WB, IHC-P, FACS, IF
Buffer: N/A
Limitation: This IRF3 antibody is available for research use only.
Purity: Protein G affinity
Description: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Immunogen: Recombinant human protein was used as the immunogen for the IRF3 antibody.
Storage: Aliquot the IRF3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
