IRAK4 Kinase Assay Kit | 78524

IRAK4 Kinase Assay Kit | 78524 | Gentaur US, UK & Europe Disrtribition

Category: Kinase/Assay Kit

Application: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.

Background: IRAKs (interleukin receptor associated kinases) are a family of Serine/Threonine kinases that induce a protective acute inflammation response, as well as an adaptive immune response in the presence of pathogens. They are associated with Toll-like receptors in immune cells and transduce an intracellular signaling cascade that results in the transcription of genes involved in inflammation. Four IRAK-like molecules have been identified IRAK1, IRAK2, IRAK4 and IRAKM. IRAK1 and IRAK4 are active kinases, while IRAK2 and IRAKM are inactive.  All four kinases mediate activation of NFκB (nuclear factor kappa B), a regulator of innate immunity through signaling pathways that link pathogenic and cellular danger signals in response to invading pathogens. IRAKs have the potential to be used as therapeutic targets due to their highly functional role as mediators of immune response.

Description: The IRAK4 Kinase Assay Kit is designed to measure IRAK4 kinase activity for screening and profiling applications using ADP-Glo^® as a detection reagent. 

Product Type: Assay Kit

Shippement Condition: -80°C