Description
Insulin Receptor Antibody | F50643-0.05ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS pH 7.4 with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: IHC, WB, ELISA
Buffer: N/A
Limitation: This Insulin Receptor antibody is available for research use only.
Purity: Purified
Description: INSR binds insulin and has a tyrosine-protein kinase activity. Autophosphorylation activates the kinase activity. This Type I mebrane protein is composed of a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to the plasma membrane.
Immunogen: A portion of amino acids 21-52 from the human protein was used as the immunogen for this Insulin Receptor antibody.
Storage: Aliquot the Insulin Receptor antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
