Inhibitor

GC376 | 78013 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitor Application: Study enzyme kinetics and HTS applications in drug discovery. Background: N/A Description: GC376 a 3CL protease inhibitor is optimized for use...

UNC0321 (TFA salt) | 27306 | Gentaur US, UK & Europe Disrtribition Category: Methyltransferase/Inhibitors / Activators Application: N/A Background: N/A Description: UNC0321 (trifluoroacetate salt) is a selective histone lysine...

(+)-JQ1 | 27402 | Gentaur US, UK & Europe Disrtribition Category: Bromodomain/Inhibitors / Activators Application: N/A Background: N/A Description: (+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs,...

Aliskiren Hydrochloride | 27300 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitors / Activators Application: N/A Background: N/A Description: Aliskiren Hydrochloride is an orally active, synthetic nonpeptide Renin inhibitor...

(S)-MG132 | 27230 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Ubiquitination Application: N/A Background: N/A Description: (S)-MG132, also known as Z-Leu-Leu-Leu-CHO, is a potent, reversible and cell-permeable...

BAY-11-7082 | 27229 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Other Application: N/A Background: N/A Description: BAY-11-7082 is a selective and irreversible inhibitor of NF-κB activation by blocking...

AGK2 | 27228 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: AGK2 is a selective, cell-permeable inhibitor of SIRT2. It has minimal effects SIRT1 and SIRT3 at...

IU1 | 27227 | Gentaur US, UK & Europe Disrtribition Category: Ubiquitination/Inhibitors / Activators Application: N/A Background: N/A Description: IU1 is a small molecule, reversible inhibitor of deubiquitination by USP14. It selectively...

(R)-MG132 | 27226 | Gentaur US, UK & Europe Disrtribition Category: Ubiquitination/Inhibitors / Activators Application: N/A Background: N/A Description: (R)-MG132 is a potent, cell permeable and reversible inhibitor of proteasomes. It can...

Clasto-lactacystin β-lactone | 27224 | Gentaur US, UK & Europe Disrtribition Category: Ubiquitination/Inhibitors / Activators Application: N/A Background: N/A Description: Clasto-lactacystin β-lactone, also known as Omuralide and...

UNC0638 | 27222 | Gentaur US, UK & Europe Disrtribition Category: Methyltransferase/Inhibitors / Activators Application: N/A Background: N/A Description: UNC0638 is a selective inhibitor of G9a and G9a-like protein (GLP), also known as EHMT1,...

Chaetocin | 27221 | Gentaur US, UK & Europe Disrtribition Category: Methyltransferase/Inhibitors / Activators Application: N/A Background: N/A Description: Chaetocin is an inhibitor of histone methyltransferases (HMTs) including SUV39H1 and...

BIX01294 (hydrochloride hydrate) | 27220 | Gentaur US, UK & Europe Disrtribition Category: Methyltransferase/Inhibitors / Activators Application: N/A Background: N/A Description: BIX01294 (hydrochloride hydrate) is a selective inhibitor of...

Ellagic acid | 27219 | Gentaur US, UK & Europe Disrtribition Category: Methyltransferase/Inhibitors / Activators Application: N/A Background: N/A Description: Ellagic acid, also known as TBBD, Gallogen, and Lagistase, can alter cytochrome...

Zaprinast | 27218 | Gentaur US, UK & Europe Disrtribition Category: Phosphodiesterase/Inhibitors / Activators Application: N/A Background: N/A Description: Zaprinast is a cGMP-specific PDE inhibitor which moderately inhibits PDE5 and PDE6. It...

Icariin | 27217 | Gentaur US, UK & Europe Disrtribition Category: Phosphodiesterase/Inhibitors / Activators Application: N/A Background: N/A Description: Icariin is a PDE5 inhibitor. It is the active component of the Chinese medicinal plant E...

Milrinone | 27216 | Gentaur US, UK & Europe Disrtribition Category: Phosphodiesterase/Inhibitors / Activators Application: N/A Background: N/A Description: Milrinone, also known as WIN 47203 and Primacor®, is an inhibitor of PDE3. It is less...

BAY-60-7550 | 27215 | Gentaur US, UK & Europe Disrtribition Category: Phosphodiesterase/Inhibitors / Activators Application: N/A Background: N/A Description: BAY-60-7550 is a potent inhibitor of PDE2. It is more selective for PDE2 than PDE1...

Quercetin | 27214 | Gentaur US, UK & Europe Disrtribition Category: Phosphodiesterase/Inhibitors / Activators Application: N/A Background: N/A Description: Quercetin is an inhibitor of PDEs of both cAMP and cGMP. It is a flavonoid found in...

IBMX | 27213 | Gentaur US, UK & Europe Disrtribition Category: Phosphodiesterase/Inhibitors / Activators Application: N/A Background: N/A Description: IBMX, also known as 1-Methyl-3-Isobutylxanthine and Isobutylmethylxanthine, is a...

LY171883 | 27211 | Gentaur US, UK & Europe Disrtribition Category: Phosphodiesterase/Inhibitors / Activators Application: N/A Background: N/A Description: LY171883 is a PDE inhibitor and a selective, potent inhibitor of the leukotriene D4...

Suberohydroxamic Acid (SBHA) | 27210 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Suberohydroxamic acid (SBHA) is a competitive HDAC inhibitor. SBHA has...

HC Toxin | 27209 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: HC Toxin is a reversible, cell-permeable inhibitor of HDACs. It is a cyclic tetrapeptide...

Valproic Acid | 27207 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Valproic acid inhibits histone deacetylases (HDACs), in particular Class I HDACs. It is...

HNHA | 27206 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity. HNHA induces histone...

4-iodo-SAHA | 27205 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: 4-iodo-SAHA is a hydrophobic derivative of SAHA, a class I and class II histone...

CBHA | 27204 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: M-Carboxycinnamic Acid bishydroxamide, or CBHA, is a potent histone deacetylase (HDAC) inhibitor...

M344 | 27203 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: M344 is a histone deacetylase (HDAC) inhibitor also known as D237 or MS 344. It inhibits human...

Chidamide | 27202 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Chidamide is a histone deacetylase inhibitor which increases Histone H3 acetylation levels...

Oxamflatin | 27201 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Oxamflatin is a potent inhibitor of histone deacetylases. It has the ability to alter...

Scriptaid | 27200 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Scriptaid, also known as GCK 1026, is a histone deacetylase inhibitor with optimal...

RVX-208 | 27111 | Gentaur US, UK & Europe Disrtribition Category: Bromodomain/Inhibitors / Activators Application: Useful as a BET Bromodomain inhibitor. Background: N/A Description: RVX-028, also known as RVX-000222, is a potent BET...

Mocetinostat (MGCD0103) | 27109 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Deacetylase Application: N/A Background: N/A Description: Mocetinostat (MGCD0103) is an HDAC inhibitor. It was shown to induce...

Tubastatin A hydrochloride | 27108 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Tubastatin A is a potent HDAC6 inhibitor. It demonstrates over 1,000-fold...

Azacytidine (Vidaza) | 27107 | Gentaur US, UK & Europe Disrtribition Category: Methyltransferase/Inhibitors / Activators Application: N/A Background: N/A Description: Azacitidine is also known as Vidaza, 5-azacytidine, Mylosar, and...

Sitagliptin | 27106 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitors / Activators Application: N/A Background: N/A Description: Sitagliptin, also known as MK-0431 and Januvia, is a Dipeptidyl Peptidase IV Inhibitor. ...

Sildenafil Citrate | 27105 | Gentaur US, UK & Europe Disrtribition Category: Phosphodiesterase/Inhibitors / Activators Application: N/A Background: N/A Description: Sildenafil citrate, also known as Revatio, acts by inhibiting cGMP specific...

Curcumin | 27104 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Other Application: N/A Background: N/A Description: Curcumin, also known as diferuloylmethane, natural yellow 3, or C.I. 75300, is the principal...

EX527 | 27103 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor. It is...

Trichostatin A (TSA) | 27102 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Trichostatin A (TSA) is an antifungal antibiotic with cytostatic and...

ABT-888 (Veliparib) | 27101 | Gentaur US, UK & Europe Disrtribition Category: PARP/Inhibitors / Activators Application: N/A Background: N/A Description: ABT-888 (Veliparib) is a potent inhibitor of both PARP-1 and PARP-2. In the MX-1 breast...

XAV939 | 27100 | Gentaur US, UK & Europe Disrtribition Category: PARP/Inhibitors / Activators Application: N/A Background: N/A Description: XAV 939 is a small molecule and selective Wnt pathway transcription factor - catenin-mediated...

Forskolin | 27068 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Other Application: Forskolin is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Background: N/A ...

Forskolin | 27067 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Other Application: Forskolin is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Background: N/A ...

Axitinib | 27064 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Axitinib (AG-013736) is an oral, potent, and selective inhibitor of vascular endothelial growth factor...

PP242 | 27063 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: PP242 is an inhibitor at the kinase domain of the mammalian target of rapamycin (mTOR), which is a Ser/Thr...

Rapamycin | 27062 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed...

A-769662 | 27057 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: A-769662 is a potent, reversible activator of AMP-activated protein kinase (AMPK). AMPK is an αβγ...

PD 173074 | 27056 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: PD 173074 inhibited the kinase activity of FGFR1 with an IC50 of 25 nM in vitro, while inhibiting Src,...

Camostat Mesilate (FOY-305) | 27055 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitors / Activators Application: N/A Background: N/A Description: Orally active protease inhibitor. Known to inhibit trypsin and various...

BMS-790052 | 27054 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitors / Activators Application: N/A Background: N/A Description: BMS-790052 is a highly selective and highly potent inhibitor of hepatitis C virus (HCV) NS5A...

VX-222 | 27053 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitors / Activators Application: N/A Background: N/A Description: VX-222 is a novel, potent and selective inhibitor of non-nucleoside polymerase of the hepatitis C...

Danoprevir | 27052 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitors / Activators Application: N/A Background: N/A Description: Danoprevir is a peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV)...

Telaprevir (VX-950) | 27051 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitors / Activators Application: N/A Background: N/A Description: Telaprevir inhibits the hepatitis C virus NS3-4A serine protease, leading to the...

Okadaic Acid | 27047 | Gentaur US, UK & Europe Disrtribition Category: Phosphatase/Inhibitor Application: N/A Background: N/A Description: Potent inhibitor of protein phosphatases, especially the PP-1 and PP-2 classes, in numerous cell types...

BIIB021 | 27046 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Other Application: N/A Background: N/A Description: BIIB021 is an orally available, synthetic small-molecule Hsp90 inhibitor. It binds in the...

Obatoclax | 27044 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitors / Activators Application: N/A Background: N/A Description: Obatoclax, also known as GX15-070, is a novel Bcl-2 homology domain-3 (BH3) mimetic. It...

(+)-JQ1 | 27401 | Gentaur US, UK & Europe Disrtribition Category: Bromodomain/Inhibitors / Activators Application: N/A Background: N/A Description: (+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs,...

Roscovitine | 27040 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Roscovitine is a potent inhibitor of p34cdc2 (IC50 = 0.2 µM). Also inhibits p33cdk2 and p33cdk5. ...

LY-294002 | 27038 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Specific inhibitor (IC50 = 1.40 µM) of phosphatidylinositol 3-kinase (PI3K). Product Type: ...

Tofacitinib | 27037 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Tofacitinib, also known as Tasocitinib, is a novel inhibitor of Janus kinase 3 (JAK3), a critical...

Cediranib | 27036 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Cediranib, also known as AZD2171, is a highly potent inhibitor of recombinant KDR tyrosine kinase...

Doramapimod | 27034 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12...

K252a | 27033 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: K252a is a general kinase inhibitor that inhibits PKA (Ki = 18 nM), PKC (Ki = 25 nM), PKG (Ki = 20 nM),...

Gefitinib | 27032 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Gefitinib is a tyrosine kinase inhibitor. It is a potent inhibitor of EGFR kinase (Ki = 0.40 nM), but...

Wortmannin | 27031 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and...

HA-1077 | 27030 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Dihydrochloride form of HA-1077. Inhibits a number of kinases, including ROCK I (IC50 = 10.7 µM), ROCK II...

Fasudil | 27029 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Monohydrochloride form of HA-1077. Inhibits a number of kinases, including ROCK I (IC50 = 10.7 µM), ROCK...

Bortezomib | 27028 | Gentaur US, UK & Europe Disrtribition Category: Protease/Inhibitors / Activators Application: N/A Background: N/A Description: Potent (Ki, 0.6 nM), specific and reversible proteasome inhibitor; no significant inhibitory...

17-AAG | 27027 | Gentaur US, UK & Europe Disrtribition Category: Heat Shock Protein/Inhibitors / Activators Application: N/A Background: N/A Description: 17-AAG binds specifically to heat shock protein Hsp90 in a manner similar to...

NVP-AUY922 | 27026 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Other Application: N/A Background: Heat shock protein 90 (HSP90) is a molecular chaperone essential for the stability of key regulators of cell growth...

Temsirolimus | 27024 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Temsirolimus, a rapamycin (sirolimus) derivative, also known as CCI-779, is an mTOR inhibitor with...

SP600125 | 27023 | Gentaur US, UK & Europe Disrtribition Category: Phosphodiesterase/Inhibitors / Activators Application: N/A Background: N/A Description: Novel, potent and selective JNK-1,-2, and -3 inhibitor (Ki = 0.19 µM). SP600125 is an...

CI-994 | 27021 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: CI-994 is a histone deacetylase (HDAC) inhibitor that induces histone hyperacetylation. CI-994...

Panobinostat | 27020 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Panobinostat, also known as LBH-589, is a highly active, non-selective HDAC inhibitor...

Mocetinostat | 27019 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Mocetinostat selectively inhibits histone deacetylases (HDACs) 1-3 and 11 at...

Z-VAD-FMK, Methyl Ester | 27017 | Gentaur US, UK & Europe Disrtribition Category: Apoptosis Inhibitor Application: N/A Background: N/A Description: Z-VAD(OMe)-FMK is a cell permeable, irreversible pan-caspase inhibitor and anti-apoptotic...

Vismodegib (GDC-04491) | 27015 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Other Application: N/A Background: N/A Description: Vismodegib (GDC-0449) is a potent hedgehog (Hh) signaling pathway inhibitor. ...

Sorafenib Tosylate | 27014 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Sorafenib Tosylate, also known as Bay 43-9006, is a novel bi-aryl urea compound that inhibits...

Cyclopamine, Free Base | 27013 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Other Application: N/A Background: N/A Description: Cyclopamine inhibits activation of the Hedgehog response pathway by binding to and...

U0126 | 27012 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: U0126 is a selective inhibitor of mitogen-activated protein kinase kinases, MEK-1 and MEK-2. It is a weak...

MS-275 (Entinostat) | 27011 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: MS-275, also known as Entinostat, is an inhibitor of histone deacetylases (HDACs)...

Vismodegib (GDC-04491) | 27010 | Gentaur US, UK & Europe Disrtribition Category: Inhibitors / Activators/Other Application: N/A Background: N/A Description: Vismodegib (GDC-0449) is a potent hedgehog (Hh) signaling pathway inhibitor. ...

Afatinib | 27009 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: Afatinib, also known as BIW-2992, is an irreversible dual inhibitor of epidermal growth factor receptor...

Geldanamycin | 27008 | Gentaur US, UK & Europe Disrtribition Category: Heat Shock Protein/Inhibitor Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling Background: N/A Description: ...

SAHA (Vorinostat) | 27006 | Gentaur US, UK & Europe Disrtribition Category: Deacetylase/Inhibitors / Activators Application: N/A Background: N/A Description: Soruberoylanilide Hydroxamic Acid (SAHA), or Vorinostat, is a histone deacetylase...

AZD2281 (Olaparib) | 27003 | Gentaur US, UK & Europe Disrtribition Category: PARP/Inhibitors / Activators Application: N/A Background: N/A Description: AZD2281, also known as Olaparib, is a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor and...

GDC-0941 | 27000 | Gentaur US, UK & Europe Disrtribition Category: Kinase/Kinase Inhibitors Application: N/A Background: N/A Description: GDC-0941, also known as Pictilisib, is a phosphatidylinositol 3-kinase (PI3K) inhibitor Product Type: ...