Description
IL6R Polyclonal Antibody | E-AB-40344 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Application: WB, IHC
Research Area: Cancer, Immunology, Stem Cells
Background: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Lead Time: 7~10 days
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant Human Interleukin-6 receptor subunit alpha protein
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification: Antigen Affinity Purification
Dilution: WB 1:1000-1:2000 IHC 1:100-1:300
Conjugation: Unconjugated
Calculated Molecular Weight: 40, 51 kDa
Observed Molecular Weight: 80 kDa
Clonality: Polyclonal
