IL-4Rα [Biotinylated]: IL-4 Inhibitor Screening ELISA Kit | EP-142-96tests

IL-4Rα [Biotinylated]: IL-4 Inhibitor Screening ELISA Kit | EP-142| Gentaur Distribution US, UK & Europe

Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells) . In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine.

Source: Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells) . In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine.

Molecule: ILN/A4Rα.

Format: Solid.

Species: Human.

Application: This kit is developed for screening for inhibitors of human IL-4Rα binding to human IL-4.

Kit Component: This inhibitor screening ELISA kit is designed to facilitate the identification and characterization of new IL-4 Rα pathway inhibitors. The assay takes advantage of our in house-developed binding of biotinylated human IL-4 Rα to immobilized human IL-4 in a functional ELISA assay, and employs a simple colorimetric ELISA platform. Briefly, we provide you with a human Biotinylated IL-4 Rα protein, a human IL-4 protein, an anti-IL-4Rα neutralizing antibody (as method verified Std.), and Streptavidin-HRP reagent.

Stability: The unopened kit is stable for 12 months from the date of manufacture if stored at 2°C to 8°C. The opened kit should be stored per components table. The shelf life is 30 days from the date of opening.

Storage Conditions: 2-8℃.

Shipping Conditions: RT