IL-17RA:IL-17A[Biotin] Inhibitor Screening Assay Kit | 79891

IL-17RA:IL-17A[Biotin] Inhibitor Screening Assay Kit | 79891 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Assay Kit

Application: Great for screening small molecules and antibodies that inhibit the binding of IL-17A to IL-17RA.

Background: IL-17A is a pro-inflammatory cytokine produced by TH17 cells that plays a key role in inflammation, autoimmunity, and host defense. It has been shown to stimulate the production of pro-inflammatory cytokines, namely IL-6 and IL-8, by synoviocytes. Due to its role as a mediator of inflammation, the IL-17 pathway has become a popular target for treating diseases that have a strong inflammatory component such as psoriasis, arthritis, Crohn's disease, and ankylosing spondylitis.

Description: The IL-17RA:IL-17A[Biotin] Inhibitor Screening Assay Kit is designed for screening inhibitors of IL-17A:IL-17RA interaction. The key to this kit is the high sensitivity of detection of biotin-labeled IL-17A by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, IL-17RA is coated on a 96-well plate. Next, IL-17A[Biotin] is incubated with IL-17RA on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can then be measured using a chemiluminescence reader.

Product Type: Assay Kit

Shippement Condition: -80°C