IKKb Antibody | N1030-25UG

IKKb Antibody | N1030-25UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: IKB355

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse

Application: WB

Buffer: 1X PBS, pH 7.4

Limitation: This IKKb antibody is available for research use only.

Purity: Protein G purified antibody

Description: NF-kB is sequestered in the cytoplasm by IkBa, unable to translocate to the nucleus. IkB is part of the canonical pathway for NF-kB activation. IKKb is part of the IkB kinase complex, along with a second catalytic subunit, IKKa, and a regulatory subunit, IKKg. Along with IKKa, IKKb phosphorylates IkBa leading to its degradation and release of inhibition of NF-kB. The RELA subunit of active NF-kB is then free to enter the nucleus and initiate a number of signaling cascades.

Immunogen: A recombinant protein fragment of IKKb was used as the immunogen for this antibody.

Storage: Aliquot the IKKb antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.