Description
IKKb Antibody | N1030-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: IKB355
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human, Mouse
Application: WB
Buffer: 1X PBS, pH 7.4
Limitation: This IKKb antibody is available for research use only.
Purity: Protein G purified antibody
Description: NF-kB is sequestered in the cytoplasm by IkBa, unable to translocate to the nucleus. IkB is part of the canonical pathway for NF-kB activation. IKKb is part of the IkB kinase complex, along with a second catalytic subunit, IKKa, and a regulatory subunit, IKKg. Along with IKKa, IKKb phosphorylates IkBa leading to its degradation and release of inhibition of NF-kB. The RELA subunit of active NF-kB is then free to enter the nucleus and initiate a number of signaling cascades.
Immunogen: A recombinant protein fragment of IKKb was used as the immunogen for this antibody.
Storage: Aliquot the IKKb antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
