IKK beta Antibody (phospho-S670) | F48701-0.08ML

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SKU:
800-F48701-0.08ML
Weight:
1.20 KGS
€644.00
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Description

IKK beta Antibody (phospho-S670) | F48701-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: DB, ELISA

Buffer: N/A

Limitation: This phospho-IKK beta antibody is available for research use only.

Purity: Antigen affinity

Description: NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Immunogen: This phospho-IKK beta antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS670 of human IKKB.

Storage: Aliquot the phospho-IKK beta antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.

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Additional Information

Size:
0.08 mL
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