IkBa Antibody | R31704

IkBa Antibody | R31704 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5mg/ml if reconstituted with 0.2ml sterile DI water

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: WB, IHC-P

Buffer: N/A

Limitation: This IkBa antibody is available for research use only.

Purity: Antigen affinity

Description: NFKBIA, also called IkBa or MAD-3, is one member of a family of cellular proteins that function to inhibit the NF-kB transcription factor. It inhibits NF-kB by masking the nuclear localization signals (NLS) of NF-kB proteins and keeping them sequestered in an inactive state in the cytoplasm. It moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. The effect of the nonpathogenic bacteria is specific to the SCF complex substrates beta Catenin and IkBa. This may help to explain the beneficial effects of treatment of inflammatory bowel disease with nonpathogenic probiotic enteric organisms. In addition, IkBa blocks the ability of NFkB transcription factors to bind to DNA, which is required for proper NFkB functioning.

Immunogen: Human partial recombinant protein (AA 3-112) was used as the immunogen for this IkBa antibody.

Storage: After reconstitution, the IkBa antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 °C. Avoid repeated freezing and thawing.