Description
IFNAR1 Antibody / Interferon alpha receptor 1 | RQ4481 | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol
Format: Purified
Clone: AF-9
Host: Rabbit
Clonality: Recombinant Rabbit Monoclonal
Isotype: Rabbit IgG
Species Reactivity: Human
Application: WB
Application Details: Western blot: 1:500-1:2000
Application Note: Optimal dilution of the IFNAR1 antibody should be determined by the researcher.
Purity: Protein A affinity
Description: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). [UniProt]
Immunogen: A synthetic peptide from human Interferon Receptor alpha was used as the immunogen for the IFNAR1 antibody.
Storage: Store the IFNAR1 antibody at -20 °C.
Localization: Cell membrane, Cytoplasm
