IFNAR1 Antibody / Interferon alpha receptor 1 | RQ4481

IFNAR1 Antibody / Interferon alpha receptor 1 | RQ4481 | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: Antibody in PBS with 0.02% sodium azide and 50% glycerol

Format: Purified

Clone: AF-9

Host: Rabbit

Clonality: Recombinant Rabbit Monoclonal

Isotype: Rabbit IgG

Species Reactivity: Human

Application: WB

Application Details: Western blot: 1:500-1:2000

Application Note: Optimal dilution of the IFNAR1 antibody should be determined by the researcher.

Purity: Protein A affinity

Description: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). [UniProt]

Immunogen: A synthetic peptide from human Interferon Receptor alpha was used as the immunogen for the IFNAR1 antibody.

Storage: Store the IFNAR1 antibody at -20 °C.

Localization: Cell membrane, Cytoplasm