Description
IDO2 - HEK293 Recombinant Cell Line (Human) | 60533 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: Monitor IDO2 pathway activity. Screen for activators or inhibitors of IDO2 in a cellular context.
Background: L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells.The L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp. Additionally, the released degradation products of L-Trp have immunosuppressive functions. Indoleamine 2,3-dioxygenases (IDO1 & IDO2), two of the rate limiting enzymes in this pathway, are upregulated in many tumorsand provide cancer cells with an avenue for immune evasion.
Description: Recombinant HEK293 cell line expressing tetracycline-inducible human indoleamine 2,3-dioxygenase (IDO2), Genbank accession number NM_194294.
Product Type: Cell Line
Shippement Condition: -80°C
