Description
IDO1-HEK293 Recombinant Cell line | 60532 | Gentaur US, UK & Europe Disrtribition
Category: Immunotherapy/Cell Line
Application: Monitor IDO1 pathway activity. Screen for activators or inhibitors of IDO1 in a cellular context
Background: L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions. Indoleamine 2,3- dioxygenases (IDO1 & IDO2), two of the rate limiting enzymes in this pathway, are upregulated in many tumors, providing cancer cells with an avenue for immune evasion.
Description: Stable Recombinant HEK293 cell line expressing tetracycline-inducible human indoleamine 2,3-dioxygenase (IDO1) Genbank accession number NM_002164.
Product Type: Cell Line
Shippement Condition: -80°C (dry ice)
