Description
IDH2 (R140Q), FLAG-tag | 71100-1 | Gentaur US, UK & Europe Disrtribition
Category: Metabolic Enzymes/Protein
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). The IDH2 homodimer is an the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production and may tightly associate or interact with the pyruvate dehydrogenase complex.
Description: Human isocitrate dehydrogenase 2, also known as IDH2, GenBank Accession No. NM_002168, a.a. 1-452(end) with with Arg to Gln mutation on a.a. 140 and C-terminal FLAG-tag, MW = 52 kDa, expressed in a baculovirus infected Sf9 cell expression system.
Product Type: Protein
Shippement Condition: -80°C
