IDH2(R140Q) Assay Kit | 79309

IDH2(R140Q) Assay Kit | 79309 | Gentaur US, UK & Europe Disrtribition

Category: Metabolic Enzymes/Assay Kit

Application: Useful for screening small molecular inhibitors for drug discovery and HTS applications.

Background: Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have been reported in a multitude of human cancers. While the wild type IDH2, produces α-ketoglutarate (α-KG) through the reduction of NADP+ to NADPH, the IDH2(R140Q) mutant catalyzes conversion of α-ketoglutarate to 2-hydroxy-glutarate (2-HG) by oxidizing NADPH to NADP+. Genomic studies have identified the IDH2(R140Q) mutation in various cancer types, including as glioma, chondrosarcoma, AML as well as small percentage of prostate, lung and colon cancers.

Description: The IDH2(R140Q) Assay Kit is designed to measure IDH2(R140Q) activity for screening and profiling applications by measuring NADPH consumption.

Product Type: Assay Kit

Shippement Condition: -80°C