Description
ICOS/NFAT Reporter-Jurkat Recombinant Cell Line | 79668 | Gentaur US, UK & Europe Disrtribition
Category: Cell Line/Reporter Cell Line & Cell-Based Assays
Application: • Screen for agonists of ICOS signaling in a physiologically relevant cellular context
• Characterize T cell-mediated immune responses of ICOS and its interaction with ICOSL
Background: ICOS is a costimulatory molecule of the CD28 cell surface receptor superfamily that is expressed on activated T-cells. ICOS is involved in T-cell responses upon binding with its ligand, ICOSL (also known as B7-H2, CD275), which is normally expressed on B-cells, dendritic cells and monocytes. ICOS expression confers an activated phenotype and a strong suppressive capacity to intra-tumoral regulatory T-cells. The ICOS/ICOSL pathway is a key target for cancer immunotherapy.
Description: Recombinant Jurkat T cell expressing firefly luciferase gene under the control of NFAT response elements with constitutive expression of a chimeric receptor consisting human ICOS (also known as inducible T-cell costimulator or CD278, Genbank Accession #NM_012092) and the cytoplasmic domain of human CD3 zeta.
Product Type: Cell Line
Shippement Condition: -80°C
