ICOS-L Antibody / ICOS Ligand / B7RP-1 | V7774-100UG

ICOS-L Antibody / ICOS Ligand / B7RP-1 | V7774-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: ICOSL/3260

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: ELISA, IHC-P

Buffer: N/A

Limitation: This ICOS Ligand antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: This MAb recognizes a protein of 36kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.

Immunogen: A recombinant human partial protein (amino acids 23-149) was used as the immunogen for the ICOS Ligand antibody.

Storage: Store the ICOS Ligand antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).