Description
ICAM1 Antibody / CD54 | V2605SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: F4-31C2
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: Functional studies, FACS, IF
Buffer: N/A
Limitation: This ICAM1 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Recognizes an 85-115kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1). It has 7 potential N-linked glycosylation sites. ICAM1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM1 also binds to CD43 and to Plasmodium falciparum infected RBCs and may also be related to progression and metastasis of tumors.
Immunogen: Human umbilical cord vein endothelial cells (HUVEC) were used as the immunogen for the ICAM1 antibody.
Storage: Store the ICAM1 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
