ICAD Antibody | N1102-25UG

ICAD Antibody | N1102-25UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Mouse

Application: WB

Buffer: 1X PBS, pH 7.4

Limitation: This ICAD antibody is available for research use only.

Purity: Protein A affinity chromatography

Description: During apoptosis, toxic or useless cells are broken down for removal. DFF, or DNA fragmentation factor, is a heterodimeric protein which mediates DNA fragmentation and chromatin condensation during apoptosis. DFFB is the active DFF subunit but remains inactive while bound to DFFA, also call ICAD (Inhibitor of caspase-activated DNase). Caspase-3 cleaves ICAD, which then disassociates from DFFB. The disassociation removes the inhibitory effects of ICAD, activating DFFB and beginning the DNA fragmentation process.

Immunogen: A recombinant protein fragment from human ICAD was used as the immunogen for this antibody.

Storage: Aliquot the antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.