Description
ICAD Antibody | N1102-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Mouse
Application: WB
Buffer: 1X PBS, pH 7.4
Limitation: This ICAD antibody is available for research use only.
Purity: Protein A affinity chromatography
Description: During apoptosis, toxic or useless cells are broken down for removal. DFF, or DNA fragmentation factor, is a heterodimeric protein which mediates DNA fragmentation and chromatin condensation during apoptosis. DFFB is the active DFF subunit but remains inactive while bound to DFFA, also call ICAD (Inhibitor of caspase-activated DNase). Caspase-3 cleaves ICAD, which then disassociates from DFFB. The disassociation removes the inhibitory effects of ICAD, activating DFFB and beginning the DNA fragmentation process.
Immunogen: A recombinant protein fragment from human ICAD was used as the immunogen for this antibody.
Storage: Aliquot the antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
