HVEM - HEK293 Recombinant Cell Line | 79313

HVEM - HEK293 Recombinant Cell Line | 79313 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Cell Line

Application: • HVEM binding molecule (such as anti-HVEM antibody) screening and profiling in a cellular context • Binding studies using HVEM ligands

Background: HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Alternately, interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.

Description: Recombinant HEK293 stably expressing human HVEM (Herpesvirus entry mediator; CD270; TNFRSF14; ATAR) GenBank Accession # NM_003820).

Product Type: Cell Line

Shippement Condition: -80°C