HVEM - CHO Recombinant Cell Line | 79297

HVEM - CHO Recombinant Cell Line | 79297 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Cell Line

Application: HVEM binding molecule (such as anti-HVEM antibody) screening and profiling in a cellular context

Background: HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT (CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory signal which negatively regulates T-cell immune responses. HVEM has also been shown to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex virus (HSV) cellular entry.

Description: Recombinant CHO-K1 stably expressing human HVEM (TNF receptor superfamily member 14; TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; GenBank Accession #NM_003820).

Product Type: Cell Line

Shippement Condition: -80°C