Description
Human TYRO3 / Dtk Protein, Fc Tag | TY3-H5251-1mg| Gentaur Distribution US, UK & Europe
Tyrosine-protein kinase receptor TYRO3 is also known as Tyrosine-protein kinase BYK, DTK, RSE, SKY, TIF, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. TYRO3 regulates many physiological processes including cell survival, migration and differentiation. TYRO3 activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 By similarity and also interacts with PIK3R1, this interaction increases PI3-kinase activity.
Source: Human TYRO3, Fc Tag (TY3-H5251) is expressed from human 293 cells (HEK293). It contains AA Ala 41 - Ser 428 (Accession # AAH51756.1 (Q261H) ).
Format: Powder.
Tag: C-Fc.
Expression System: HEK293.
Expression Region: Ala 41 - Ser 428.
Conjugate: Unconjugated.
Molecular Weight: 68.2 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 68.2 kDa. The protein migrates as 86-106 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 95%.
Buffer: Tris with Glycine, Arginine and NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
