Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag | TR1-H5228-100ug

Human TRAIL R1 / DR4 / TNFRSF10A Protein, His Tag | TR1-H5228-100ug| Gentaur Distribution US, UK & Europe

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.

Source: Human TRAIL R1, His Tag (TR1-H5228) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Asn 239 (Accession # O00220-1).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Ala 24 - Asn 239.

Conjugate: Unconjugated.

Molecular Weight: 24.8 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.8 kDa. The protein migrates as 20-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT