Description
Human TOP2A / TOP2 Protein, Tag Free | TOA-H5117-500ug| Gentaur Distribution US, UK & Europe
DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2. It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation. Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.
Source: Human TOP2A, Tag Free (TOA-H5117) is expressed from E. coli cells. It contains AA Ser 1354 - Ser 1473 (Accession # P11388-1).
Format: Liquid.
Tag: Native.
Expression System: E. coli.
Expression Region: Ser 1354 - Ser 1473.
Conjugate: Unconjugated.
Molecular Weight: 12.8 kDa.
Characteristics: This protein carries no "tag". The protein has a calculated MW of 12.8 kDa. The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE).
Purity: 90%.
Buffer: 50 mM Tris, 0.5 M KCl, pH8.0.
Storage Conditions: -70℃.
Shipping Conditions: Dry ice
