Description
Human TDP-43 Protein, His Tag | TD3-H5145-500ug| Gentaur Distribution US, UK & Europe
TDP-43, the transactive response (TAR) -DNA binding Protein with a molecular weight of 43 KDa is encoded by TARDBP gene that located at the chromosome 1. It is a RNA/DNA binding protein that structurally resembles a typical hnRNP protein family member. involved in transcriptional regulation and RNA processing. It is linked to sporadic and familial amyotrophic lateral sclerosis and frontotemporal lobar degeneration. TDP-43 is predominantly nuclear, but it translocates to the cytoplasm under pathological conditions. Cytoplasmic accumulation, phosphorylation, ubiquitination and truncation of TDP-43 are the main hallmarks of TDP-43 proteinopathies.
Source: Human TDP-43, His Tag (TD3-H5145) is expressed from E.coli cells. It contains AA Met 1 - Met 414 (Accession # Q13148-1).
Format: Liquid.
Tag: N-10×His.
Expression System: E. coli.
Expression Region: Met 1 - Met 414.
Conjugate: Unconjugated.
Molecular Weight: 46.8 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 46.8 kDa. The protein migrates as 54-56 kDa under reducing (R) condition (SDS-PAGE).
Purity: 90%.
Buffer: 50 mM HEPES, 500 mM NaCl, 0.4 M Arginine, pH8.0.
Storage Conditions: -70℃.
Shipping Conditions: Dry ice
