Human TDO Cell-Based Assay Kit | 72033

Human TDO Cell-Based Assay Kit | 72033 | Gentaur US, UK & Europe Disrtribition

Category: Immunotherapy/Cell Based Assay Kit

Application: Screen for inhibitors of hTDO enzyme in a cellular context.

Background: L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of L-Trp that have immunosuppressive functions. Tryptophan 2,3 dioxygenase (TDO), one of the rate limiting enzymes in this pathway, is upregulated in many tumors, providing cancer cells with an avenue for immune evasion.

Description: The human TDO Cell-Based Assay Kit is designed to monitor the activity of exogenously expressed human TDO in cultured cells.

Product Type: Assay Kit

Shippement Condition: -80°C (dry ice)