Human SMAC / Diablo Protein, His Tag | DIO-H5129-1mg

Human SMAC / Diablo Protein, His Tag | DIO-H5129-1mg| Gentaur Distribution US, UK & Europe

Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP), DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Source: Human SMAC, His Tag (DIO-H5129) is expressed from E.coli cells. It contains AA Ala 56 - Asp 239 (Accession # NP_063940).

Format: Powder.

Tag: C-6×His.

Expression System: E. coli.

Expression Region: Ala 56 - Asp 239.

Conjugate: Unconjugated.

Molecular Weight: 21.7 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.7 kDa. The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE).

Purity: 95%.

Buffer: 20 mM HEPES, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT