Human Siglec-10 Protein, Fc (L117A, L118A) Tag | SI0-H5254-1mg

Human Siglec-10 Protein, Fc (L117A, L118A) Tag | SI0-H5254-1mg| Gentaur Distribution US, UK & Europe

The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Source: Human Siglec-10, Fc Tag (SI0-H5254) is expressed from human 293 cells (HEK293). It contains AA Met 17 - Thr 546 (Accession # Q96LC7-1).

Format: Powder.

Tag: C-Fc (A2).

Expression System: HEK293.

Expression Region: Met 17 - Thr 546.

Conjugate: Unconjugated.

Molecular Weight: 84.6 kDa.

Characteristics: This protein carries a Fc (L117A, L118A) tag at the C-terminus. The protein has a calculated MW of 84.6 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Mutations (L117A, L118A/EU number: L234A/L235A) in human immunoglobulin G1 (hIgG1) Fc diminish binding to FcγRI leading to a significant reduction in ADCC and CDC in comparison to wild type human IgG1.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT