Human SIGIRR Protein, Fc Tag (MALS verified) | SIR-H5255-1mg

Human SIGIRR Protein, Fc Tag (MALS verified) | SIR-H5255-1mg| Gentaur Distribution US, UK & Europe

Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.

Source: Human SIGIRR, Fc Tag (SIR-H5255) is expressed from human 293 cells (HEK293). It contains AA Met 1 - His 118 (Accession # Q6IA17-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Met 1 - His 118.

Conjugate: Unconjugated.

Molecular Weight: 39.0 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.0 kDa. The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT