Human Serpin D1 / Heparin Cofactor II Protein, His Tag | HC2-H5224-50ug

Human Serpin D1 / Heparin Cofactor II Protein, His Tag | HC2-H5224-50ug| Gentaur Distribution US, UK & Europe

Serpin D1 is also known as Heparin cofactor 2 (HCF2), Protease inhibitor leuserpin-2 (HLS2), Heparin cofactor II (HC-II), which belongs to the serpin family. HCF2 is expressed predominantly in liver. Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, SerpinD1 / HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). In a glycosaminoglycan-independent manner, serpinD1 / HC-II also inhibits chymotrypsin. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.

Source: Human Serpin D1, His Tag (HC2-H5224) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Ser 499 (Accession # AAH35028).

Format: Powder.

Tag: C-6×His.

Expression System: HEK293.

Expression Region: Gly 20 - Ser 499.

Conjugate: Unconjugated.

Molecular Weight: 55.7 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.7 kDa. The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 50 mM Tris, 150 mM NaCl, pH 7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT