Description
Human SDF-1 / CXCL12 Protein, His Tag | SD1-H5143-1mg| Gentaur Distribution US, UK & Europe
Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells.
Source: Human SDF-1, His Tag (SD1-H5143) is expressed from E. coli cells. It contains AA Lys 22 - Lys 89 (Accession # P48061-2).
Format: Powder.
Tag: N-10×His.
Expression System: E. coli.
Expression Region: Lys 22 - Lys 89.
Conjugate: Unconjugated.
Molecular Weight: 10.0 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 10.0 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).
Purity: 95%.
Buffer: PBS, pH7.4.
Storage Conditions: -20℃.
Shipping Conditions: RT
