Human RNF43 Protein, Fc Tag (MALS verified) | RN3-H5256-1mg

Human RNF43 Protein, Fc Tag (MALS verified) | RN3-H5256-1mg| Gentaur Distribution US, UK & Europe

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity).

Source: Human RNF43, Fc Tag (RN3-H5256) is expressed from human 293 cells (HEK293). It contains AA Gln 44 - Tyr 197 (Accession # Q68DV7-1).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Gln 44 - Tyr 197.

Conjugate: Unconjugated.

Molecular Weight: 43.5 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 43.5 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT