Description
Human PSME3 / PA28g Protein, His Tag | PS3-H5142-1mg| Gentaur Distribution US, UK & Europe
Proteasome activator complex subunit 3 (PSME3), a member of the PA28 family, is also known as 11S regulator complex subunit gamma (REG-gamma), activator of multicatalytic protease subunit 3 and proteasome activator 28 subunit gamma (PA28gamma). PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSME3 can also facilitate the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Furthermore, PSME3 may also be involved in cell cycle regulation.
Source: Human PSME3, His Tag (PS3-H5142) is expressed from E.coli cells. It contains AA Ala 2 - Tyr 254 (Accession # P61289-1).
Format: Powder.
Tag: N-6×His.
Expression System: E. coli.
Expression Region: Ala 2 - Tyr 254.
Conjugate: Unconjugated.
Molecular Weight: 30.3 kDa.
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 30.3 kDa. The protein migrates as 28-33 kDa under reducing (R) condition (SDS-PAGE).
Purity: 95%.
Buffer: 50 mM Tris, 150 mM NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
