Description
Human PLAU / uPA Protein, His Tag | PLU-H5229-1mg| Gentaur Distribution US, UK & Europe
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
Source: Human PLAU, His Tag (PLU-H5229) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Leu 431 (Accession # NP_002649.1).
Format: Powder.
Tag: C-6×His.
Expression System: HEK293.
Expression Region: Ser 21 - Leu 431.
Conjugate: Unconjugated.
Molecular Weight: 47.2 kDa.
Characteristics: Human PLAU, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 47.2 kDa. The protein migrates as 45-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Please note that the protein is not activated by protease digestion. In vitro activation is generally recommended for higher activity..
Purity: 92%.
Buffer: 50 mM Sodium Acetate, 100 mM NaCl, pH5.0.
Storage Conditions: -20℃.
Shipping Conditions: RT
