Human OX40 Ligand / TNFSF4 Protein, Mouse IgG2a Fc Tag, low endotoxin | OXL-H5250-100ug

Human OX40 Ligand / TNFSF4 Protein, Mouse IgG2a Fc Tag, low endotoxin | OXL-H5250-100ug| Gentaur Distribution US, UK & Europe

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

Source: Human OX40 Ligand Protein, Mouse IgG2a Fc Tag (OXL-H5250) is expressed from human 293 cells (HEK293). It contains AA Gln 51 - Leu 183 (Accession # P23510-1).

Format: Powder.

Tag: C-mFc (mIgG2a).

Expression System: HEK293.

Expression Region: Gln 51 - Leu 183.

Conjugate: Unconjugated.

Molecular Weight: 42.3 kDa.

Characteristics: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 42.3 kDa. The protein migrates as 53-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT